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pentobarbital will lower the extent or influence of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Strong CYP3A4 inducers may lessen midostaurin concentrations causing minimized efficacy.pentobarbital will lessen the extent or effect of elbasvir/grazoprevir by impacting hepatic/intestin